An efficient synthesis of lactarochromal from 6-amino-2,2-dimethylchroman-4-one

Abstract

1761-1762Lactarochromal 1, a metabolite of <i style="mso-bidi-font-style: normal">Lactarius deliciosus, has been synthesised starting from 6-amino-2,2-dimethylchroman-4-one 3, which in turn, is prepared from paracetamol via the known intermediates. The amino compound <b style="mso-bidi-font-weight: normal">3 is then converted to the iodo compound <b style="mso-bidi-font-weight: normal">4, followed by formylation of the latter using N-formylpiperidine to provide, efficiently, the natural product <b style="mso-bidi-font-weight: normal">1 in good yield