<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:#131313;mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language: HI;mso-bidi-font-weight:bold" lang="EN-IN">Syntheses and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones</span>

Abstract

614-619<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">6-Aryl-2<span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#515151;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">, <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">3<span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#515151;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">, <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">4<span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#515151;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">, <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">5-tetrahydro-3-pyridazinones <span style="font-size:14.0pt; line-height:115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">(2c-22c) <span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">are obtained <span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">by dehydrocyclisation <span style="font-size:14.0pt; line-height:115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">of various <span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">h<span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3a3a3a;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">yd<span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">r<span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3a3a3a;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">azides <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">formed <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">by <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">the <span style="font-size:14.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#262626;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">reaction of appropriate methyl β-aroylpropionate and hydrazine hydrate in the presence of anhydrous sodium acetate.They show promising antiinflammatory activity during their evaluation by carrageenin induced paw edema test in <span style="font-size: 14.0pt;line-height:115%;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";color:#515151;mso-ansi-language:en-in;mso-fareast-language:="" en-us;mso-bidi-language:hi"="" lang="EN-IN">ra<span style="font-size:14.0pt; line-height:115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#131313;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-IN">ts.</span