<span style="font-size:18.0pt;mso-bidi-font-size:12.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">Studies on anti-inflammatory drugs of 2- arylpropanoic acids: Part <span style="font-size:19.5pt;mso-bidi-font-size:13.5pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">IX¹ - <span style="font-size: 18.0pt;mso-bidi-font-size:12.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA">A practical synthesis of ketoprofen by 1,2-aryl rearrangement</span></span></span>

Abstract

989-992An efficient synthesis of ketoprofen via chloration, Friedel-Crafts acylation, reduction, coupling, ketalization, rearrangement, hydrolysis and oxidation from commercially available m-bromo- benzoic acid in overall yield of about 60% has been described.</span