684-688D-004, a lipid extract of Roystonea regia fruits that contains
oleic, lauric and myristic acids as major components inhibits
α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens
and prostate trips; no study has demonstrated a similar effect for oleic,
lauric or myristic acids individually. Therefore, the effects of D-004 (250 g/ml),
oleic (100 g/ml),
lauric (50 g/ml)
or myristic (25 g/mL) acids and their combined effects on
phenylephrine (PHE: 10-7- 10-4 mol/L) induced
contractions has been studied. No treatment changed the basal tone of the
preparations, but all inhibited PHE-induced contractions. D-004 produced the
highest inhibition, followed by lauric acid, which was more effective than
myristic and oleic acids against PHE-induced contractions of control group.
D-004 and the mixture of the three acids produced similar inhibition