197-206The present
study deals with preparation, characterization and performance of chiral
selective composite membrane. The reported membranes are prepared by forming
the chiral selective layer on polysulfone (PS) microporous membrane. The chiral
selective layer is prepared in-situ on PS membrane by co-polymerization of
dibasic amino acid (lysine) and piperazine with trimesoyl chloride. The
membranes are characterized by ATR-FTIR spectroscopy and scanning electron
microscopy (SEM). The membrane performance is determined by performing optical
resolution of racemic lysine monohydrochloride in pressure driven transport.
The influence of concentration and ratio of monomers in co-polymerization on
the membrane flux, separation and enantioseparation is observed. The
observation indicates that membranes perform enantioseparation achieving >95%
enantiomeric excess (%ee) for D-lysine hydrochloride in permeate. The composite
membrane prepared with equal proportions of L-lysine and piperazine exhibited
highest %ee with reasonable flux of D-lysine hydrochloride (4.03 gm-2h-1 at 1034.21 kPa).
High enantiomeric excess is obtained with feed solutions of low concentration