1123-1130Paracetamol caused liver damage as evident
by significant increase in the activities of aspartate and alanine transferases.
There were general statistically significant losses in the activities of superoxide
dismutase, catalase, glutathione peroxidase and glutathione transferase and an
increase in thiobarbituric acid reactive substances in the liver of paracetamol
treated group compared with the control group. However, treatment with ethanol
extract of A. flos-aquae (EEAFA) was able to counteract these effects.
Protection offered by silymarin (standard reference drug) seemed relatively
greater. The results suggest that EEAFA can act as hepatoprotective agent
against paracetamol induced toxicity as an antioxidant