Synthesis of <i>syn</i>-<i>N</i>-aryl sulfonyl-4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates and their conversion to <i>ant</i>-form using DBU

Abstract

366-371Novel syn-N-arylsulfonyl-4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates have been synthesized from the corresponding -azido alcohols and converted to their anti-form by epimerizing C-2 proton using DBU. Studies on the stabilization energies are done to evaluate conversion from syn-to anti-and not the vice-versa. All the compounds have been tested for their in vitro anti-bacterial activity against S. aureus, E. faecalis and E. faecium.</i