653-661Cruciferous plants viz. cabbage,
cauliflower, turnip, radish, mustard etc. that contain goitrogenic/antithyroid
substances, constitute a portion of regular human diet. The effect of chronic
feeding of fresh and cooked radish, R.
sativus under varying state of iodine intake on morphological and
functional status of thyroid in albino rats was evaluated by thyroid gland
morphology and histology, thyroid peroxidase activity, serum triiodothyronine,
thyroxine and thyrotropin levels. The consumption pattern of iodine and
goitrogens of cyanogenic origin was evaluated by measuring urinary iodine and
thiocyanate levels respectively. After chronic radish feeding, increased weight
of thyroid gland, decreased thyroid peroxidase activity, reduced thyroid
hormone profiles and elevated level of thyrotropin were observed resembling a
relative state of hypoactive thyroid gland in comparison to control even after
supplementation of adequate iodine