Photo induced synthesis of methyl derivative of cryptosanguinolentine

Abstract

692-696A simpler method to synthesize methyl derivative of an alkaloid cryprosanguinolentine is described. 4-Hydroxy-2-methylquinoline is iodized using iodine, potassium iodide and aqueous sodium hydroxide and dehydroxyhalogenated with phosphorous oxychloride. The respective anilinoquinoline is prepared and cyclized by UV irradiation. Upon selective methylation 5,6-dimethyl-5H-indolo[3,2-c]quinoline is produced which is utilized as a DNA intercalating agent