Large local reactions to Hymenoptera stings: outcome of re-stings in real-life

Abstract

Large local reaction to Hymenoptera stings is usually defined as a swelling >10 cm which lasts longer than 24h, sometimes associated with erythema, pruritus, and blisters. Currently, the risk of subsequent systemic reactions after re-stings is considered low (2-15%). Therefore, a diagnostic work-up in case of large local reaction is often judged unnecessary, as well as adrenaline auto-injector and venom immunotherapy prescription. The aim of this study was to prospectively evaluate the outcome of re-stings in a real-world setting, in patients with a history of one previous large local reaction