Beiser, I.

Butler, J.S.

Hutchinson, M.

McGovern, E.

Molloy, A.

O'Riordan, S.

Quinlivan, B.

Redgrave, P.

Reilly, R.

Thirkettle, Martin

Williams, L.

Sheffield Hallam University Research Archive

Impaired response times to luminance stimuli in dystonia patients indicate disordered superior colliculus processingWILLIAMS, L., BUTLER, J.S., QUINLIVAN, B., MOLLOY, A., MCGOVERN, E., BEISER, I., THIRKETTLE, Martin <http://orcid.org/0000-0002-6200-3130>, O'RIORDAN, S., REDGRAVE, P., REILLY, R. and HUTCHINSON, M.Available from Sheffield Hallam University Research Archive (SHURA) at:http://shura.shu.ac.uk/22969/This document is the author deposited version.  You are advised to consult the publisher's version if you wish to cite from it.Published versionWILLIAMS, L., BUTLER, J.S., QUINLIVAN, B., MOLLOY, A., MCGOVERN, E., BEISER, I., THIRKETTLE, Martin, O'RIORDAN, S., REDGRAVE, P., REILLY, R. and HUTCHINSON, M. (2016). Impaired response times to luminance stimuli in dystonia patients indicate disordered superior colliculus processing. Movement Disorders, 31, S536-S536. Copyright and re-use policySee http://shura.shu.ac.uk/information.htmlSheffield Hallam University Research Archivehttp://shura.shu.ac.ukDate: Thursday, June 23, 2016Session Title: DystoniaSession Time: 12:00pm-1:30pmLocation: Exhibit Hall located in Hall B, Level 2Impaired response times to luminance stimuli indystonia patients indicate disordered superiorcolliculus processingL. Williams, J.S. Butler, B. Quinlivan, A. Molloy, E. McGovern, I. Beiser, M. Thirkettle, S. O'Riordan, P. Redgrave, R.Reilly, M. Hutchinson (Dublin, Ireland)Meeting: 20th International CongressAbstract Number: 1624Keywords: Dystonia: Etiology and PathogenesisSession InformationObjective: We hypothesise that patients with adult onset isolated focal dystonia (AOIFD) will have slowerreaction times to luminance stimuli versus healthy controls due to GABAergic dysfunction at a collicularlevel. Reaction times to chromatic based stimuli should be unaffected.Background: AOIFD is the most common form of dystonia yet its pathogenesis is unknown. Visual processingpathways carrying achromatic (luminance) signals – magnocellular and retinotectal routes – are faster, whilechromatic signals (parvocellular, koniocellular) which are processed  rst by the cortex, are available onlylater to the basal ganglia after cortical processing. It has been shown in Macaques that the deep layers of thesuperior colliculus (DLSC) mediate the expression cervical dystonia. The super cial layer of superiorcolliculus (SLSC) detect rapid environmental visual change via the retinotectal visual pathway, and respondby discharges to the pre-motor neurons for saccade generation and head turning. GABAergic inter-neuronsmodulate the activity of both the visual sensory receptive cells in the SLSC and the premotor neurons in theDLSC.Methods: Patients with AOIFD were recruited from a specialist dystonia outpatient clinic in St. Vincent’sUniversity Hospital, Ireland. All participants had reported normal or corrected to normal vision without anyimpairment on Ishihara testing. Healthy control participants were age and sex matched to cervical dystoniapatients. Participants sat at a computer screen in a dark room and were asked to respond to an achromatic orchromatic stimulus depending on test stage. Participants  rst completed calibration and stimuli validationtasks. Next participants were instructed to respond as fast as possible to a perceived brief change(achromatic or chromatic) in the visual stimulus.Results: Initial results show that the control participants, as excepted, were faster when responding to theachromatic change stimuli than chromatic change stimuli. While AOIFD patients gained no bene t for theachromatic change compared with the chromatic change. Interestingly, the control and AOIFD had similarresponse times for the chromatic stimuli. Full results and analysis to follow.Conclusions: These results further strengthen the hypothesis that dystonia is a GABAergic dysfunction at acollicular level.To cite this abstract in AMA style:L. Williams, J.S. Butler, B. Quinlivan, A. Molloy, E. McGovern, I. Beiser, M. Thirkettle, S. O'Riordan, P.Redgrave, R. Reilly, M. Hutchinson. Impaired response times to luminance stimuli in dystonia patientsindicate disordered superior colliculus processing [abstract]. Mov Disord. 2016; 31 (suppl 2).http://www.mdsabstracts.org/abstract/impaired-response-times-to-luminance-stimuli-in-dystonia-patients-indicate-disordered-superior-colliculus-processing/. Accessed October 16, 2018.

Impaired response times to luminance stimuli in dystonia patients indicate disordered superior colliculus processing

http://shura.shu.ac.uk/22969/1/Impaired%20response%20times%20to%20luminance%20stimuli%20in%20dystonia%20patients%20indicate%20disordered%20superior%20colliculus%20processing%20-%20MDS%20Abstracts.pdf

Impaired response times to luminance stimuli in dystonia patients indicate disordered superior colliculus processing

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