The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes
yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper(
II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography.
All of the free ligands and their metal complexes were tested for their anti-Candida activity. A
number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially
available antifungal drugs, ketoconazole and Amphotericin B
