Salt-induced hypertension has been demonstrated in a variety of species including rats,
monkeys, chimpanzees and humans. Until recently, the multiple phases of this blood pressure
increase due to high salt intake had not been closely studied. This work builds upon a
recent study, which developed a grey-boxmulti-component model of salt-induced hypertension
in the Dahl-S rat. The previous 3-component model has been extended here to include
additional model dynamics to improve the model fit and add new important elements to the
model response. The model was optimised using numerical techniques with experimental
data from 4 different protocols with Dahl-S, Dahl-R and FF2 hybrid rats. Results show a
marked improvement over the previous model and confirm the merit of the 5-component
model structure. A comparison between the model dynamics for different rat strains has
also been include