Background: Depression is a psychological change that occurs mostly in menopausal women. there are studies explaining the symptoms of depression that arise when women experience menopause and its relationship to quality of life. The purpose of this research to review evidence of the relationship between menopause and depression, and between depression and quality of life that is one of the main symptoms of menopause. Method: A systematic review was conducted based on literature published between 2002 and 2018. Using medline, science direct, JAMA, Pubmed and PsychINFO databases. The key terms "depression"," menopause "," climacterium "," quality of life ", are incorporated into the search. Results: Ten studies reported an association between menopause and depression, eight studies that investigated the association between depression and quality of life. Women with low levels of depression and a positive attitude towards menopause have positive body image values. Conclusion: There are studies that provide solid data on the prevalence of depression that meets the diagnostic criteria, as well as the suitability of the measuring instruments used to assess the quality of life. It takes a good management strategy to reduce the severity of depression so as to improve the quality of life menopausal women
