ITAGAKI Hiroko

KAMIO Takako

KOJIMAHARA Noriko

NAGASHIMA Yoji

NOGAMI Mako

OKAMAOTO Takahiro

TAMAKI Masako

Tokyo Women’s Medical University

Evaluation of 12 Prognostic Biomarkers by 10Years' Disease-Free Survival andCancer-Specific Survival Among Japanese BreastCancer Patients著者名 NOGAMI Mako, KAMIO Takako, OKAMAOTO Takahiro,TAMAKI Masako, ITAGAKI Hiroko, NAGASHIMA Yoji,KOJIMAHARA Norikojournal orpublication titleTokyo Women's Medical University Journalvolume 5page range 72-83year 2021-12-20URL http://hdl.handle.net/10470/00033121(Appendix) Nogami M et al: TWMUJ, 2021Histological GradeGrade I 202 (43.4) 17 (26.2) 13 (22.8) 22 (53.7) 117 (54.2) 30 (40.0) 3 (25.0) 0.000 (Fisher’s)Grade II 154 (33.1) 23 (35.4) 24 (42.1) 13 (31.7) 53 (24.5) 37 (49.3) 4 (33.3)Grade III 47 (10.1) 18 (27.7) 12 (21.1) 5 (12.2) 4 (1.9) 3 (4.0) 5 (41.7)Unknown 63 (13.5) 7 (10.8) 8 (14.0) 1 (2.4) 42 (19.4) 5 (6.7) 0 (0)Clinical characteristics of patients with different intrinsic subtypes of breast cancer. Descriptive summary of patient clinical characteristics among the intrinsic subtype groups.All Cases Triple NegativeHER2 Triple Positive Luminal p-valueLow Risk Intermediate RiskHigh RiskCases (%) 466 (100) 65 (14.0) 57 (12.2) 41 (8.8) 216 (46.4) 75 (16.1) 12 (2.6)Mean Age at Diagnosis (years)57.4±12.6 58.6±13.7 58.3±12.1 55.2±8.7 58.6±12.5 53.4±13.8 56.3±12.4 0.045 (ANOVA)Menopausal Status at DiagnosisPremenopausal 167 (35.8) 21 (32.3) 18 (31.6) 15 (36.6) 72 (33.3) 37 (49.3) 4 (33.3) 0.200 (Fisher’s)Postmenopausal 299 (64.2) 44 (67.7) 39 (68.4) 26 (63.4) 144 (66.7) 38 (50.7) 8 (66.7)Clinical Stage0 55 (11.8) 6 (9.2) 7 (12.3) 2 (4.9) 35 (16.2) 5 (6.7) 0 (0) 0.018 (Fisher’s)I 136 (29.1) 16 (24.6) 9 (15.8) 16 (39.0) 74 (34.3) 19 (25.3) 2 (16.7)IIA, IIB 231 (49.6) 40 (61.5) 33 (57.9) 19 (46.3) 87 (40.3) 44 (58.7) 8 (66.7)IIIA, IIIB, IIIC 40 (8.6) 2 (3.1) 7 (12.3) 4 (9.8) 19 (8.8) 6 (8.0) 2 (16.7)IV 4 (0.9) 1 (1.5) 1 (1.8) 0 (0.0) 1 (0.5) 1 (1.3) 0 (0.0)Histological TypePapillotubular carcinoma92 (19.7) 14 (21.5) 17 (29.8) 13 (31.7) 35 (16.2) 12 (16.0) 1 (8.3) 0.000 (Fisher7s)Solid-tubular carcinoma83 (17.8) 27 (41.5) 14 (24.6) 6 (14.6) 21 (9.7) 9 (12.0) 6 (50.0)Scirrhous carcinoma194 (41.6) 12 (18.5) 18 (31.6) 19 (46.3) 99 (45.8) 42 (56.0) 4 (33.3)Noninvasive carcinoma, Paget’s disease62(13.3) 6 (9.2) 7 (12.3) 2 (4.9) 42 (19.4) 5 (6.7) 0 (0.0)Others 35 (7.6) 6 (9.2) 1 (1.8) 1 (2.4) 19 (8.8) 7 (9.3) 1 (8.3)Lymphatic InvasionPositive 269 (57.7) 42 (64.6)) 31 (54.4) 27 (65.8) 118 (54.6) 43 (57.3) 8 (66.7) 0.584 (Fisher’s)Negative 197 (42.3) 23 (35.4) 26 (45.6) 14 (34.2) 98 (45.4) 32 (42.7) 4 (33.3)Blood Vessel InvasionPositive 33 (7.1) 3 (4.6) 8 (14.0) 4 (9.8) 11 (5.1) 6 (8.0) 1 (8.3) 0.202 (Fisher’s)Negative 433 (92.9) 62 (95.4) 49 (86.0) 37 (90.2) 205 (94.9) 69 (92.0) 11 (91.7)Lymph Node Metastases (N)N0 346 (74.3) 49 (75.4) 36 (63.2) 30 (73.2) 171 (79.2) 54 (72.0) 6 (50.0) 0.180 (Fisher’s)N1 117 (25.1) 16 (24.6) 21 (36.8) 11 (26.8) 42 (19.4) 21 (28.0) 6 (50.0)N2 1 (0.2) 0 (0) 0 (0) 0 (0) 1 (0) 0 (0) 0 (0)N3 2 (0.4) 0 (0) 0 (0) 0 (0) 2 (0.9) 0 (0) 0 (0)Tumor Size (T)Tis 55 (11.8) 6 (9.2) 7 (12.3) 2 (4.9) 35 (16.2) 5 (6.7) 0 (0) 0.027 (Fisher’s)T1 153 (32.8) 19 (29.2) 12 (21.1) 16 (39.0) 82 (38.0) 20 (26.7) 4 (33.3)T2 195 (41.9) 33 (50.8) 28 (49.1) 17 (41.5) 74 (34.3) 37 (49.3) 6 (50.0)T3 45 (9.7) 6 (9.2) 8 (14.0) 3 (7.3) 16 (7.4) 11 (14.7) 1 (8.3)T4b 15 (3.2) 0 (0) 1 (1.8) 2 (4.9) 9 (4.2) 2 (2.7) 1 (8.3)T4d 3 (0.64) 1 (1.5) 1 (1.8) 1 (2.4) 0 (0) 0 (0) 0 (0)Table　A.1.　Patient clinical characteristics for intrinsic subtype groups.

Evaluation of 12 Prognostic Biomarkers by 10 Years\u27 Disease-Free Survival and Cancer-Specific Survival Among Japanese Breast Cancer Patients

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Evaluation of 12 Prognostic Biomarkers by 10 Years\u27 Disease-Free Survival and Cancer-Specific Survival Among Japanese Breast Cancer Patients

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