Functional Liposomal Configuration And Method For Obtaining Said Functional Liposomal Configuration

Abstract

This invention provides a product for therapy and vaccination, constituted by a functional liposomal configuration containing complexes polynucleotides preferably on the outer surface of dehydrated-rehydrated liposomes (DRV), and the production process thereof. This functional liposomal configuration containing polynucleotides has mucoadhesion properties which allow administration by non-invasive routes, such as the nasal route, and is able to efficiently carry the polynucleotides to the interior of cells, releasing them in the cytoplasm. These properties allows for higher in vivo action efficiency of the carried polynucleotides, reduced concentration and dose frequency, and, in the case of vaccination, give protection against the specific disease. The present technology also develops a liposomal configuration carrying polynucleotides, which encode the protein HSP65, for prevention and treatment of tuberculosis.WO2009073941 (A2); WO2009073941 (A3)A61K9/127A61K9/50A61K9/51A61K31/7088WO2008BR00387A61K9/127A61K9/50A61K9/51A61K31/7088US6110745 (A)US2004043954 (A1)WO2006086330 (A2