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Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography
Authors
S. Canjau
V. Duma
+6 more
A. Manescu
M.L. Negrutiu
Adrian G.H. Podoleanu
C. Sinescu
C. Todea
F.I. Topala
Publication date
1 January 2013
Publisher
Optical Society of America
Abstract
The efforts aimed at early diagnosis of oral cancer should be prioritized towards developing a new screening instrument, based on optical coherence tomography (OCT), to be used directly intraorally, able to perform a fast, real time, 3D and non-invasive diagnosis of oral malignancies. The first step in this direction would be to optimize the OCT image interpretation of oral tissues. Therefore we propose plastination as a tissue preparation method that better preserves three-dimensional structure for study by new optical imaging techniques. The OCT and the synchrotron radiation computed microtomography (micro-CT) were employed for tissue sample analyze. For validating the OCT results we used the gold standard diagnostic procedure for any suspicious lesion - histopathology. This is a preliminary study of comparing features provided by OCT and Micro-CT. In the conditions of the present study, OCT proves to be a highly promising imaging modality. The use of x-ray based topographic imaging of small biological samples has been limited by the low intrinsic x-ray absorption of non-mineralized tissue and the lack of established contrast agents. Plastination can be used to enhance optical imagies of oral soft tissue samples. © 2013 OSA-SPIE
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Last time updated on 05/04/2016