PHARMACOKINETIC PROFILE OF 2 DIFFERENT PHARMACEUTICAL FORMS OF THEOPHYLLINE (A SLOW-RELEASE TABLET AND A SYRUP) AFTER MULTIPLE-DOSE ADMINISTRATION TO HEALTHY-HUMAN VOLUNTEERS

Abstract

Due to the narrow therapeutic range of theophylline, plasma concentrations of this drug are monitored in patients undergoing chronic therapy. Slow-release preparations avoid the fluctuations in plasma levels and improve patient compliance. In this study, we have compared the pharmacokinetic profiles of a theophylline slow-release tablet and a syrup form, when administered in multiple doses to healthy adult volunteers. The classification based upon releasing patterns is confirmed.88115515