Metabolic Oxidation Of Dipyridamole(dip) By Mouse Liver Microsomes

Abstract

A method of spectrofluorimetric monitoring of dipyridamole (DIP) metabolism has been developed. The spectrophotometric monitoring of NADPH microsomal oxidation as a measure of DIP metabolism has also been performed. The drug metabolic oxidation by microsomes requires NADPH and is accompanied by the oxidation of both cofactor and cytochrome b5. Carbon monoxide inhibits DIP metabolic oxidation.211120126Mancuso, G., (1995) Genitourinary Medicine, 71, p. 57Selley, M.L., (1994) Atherosclerosis, 111, p. 91Pospisil, M., (1995) Rad. Res., 142, p. 16Snoek, R., (1994) Antiviral Chemistry & Chemotherapy, 5, p. 312Sato, S., (1993) Anti-cancer Drug Design, 8, p. 289Damile, B.D., (1994) Int J. Cancer, 56, p. 113Vallejo, C.T., (1995) Amer. J. Clin. Oncol., 18, p. 185Ragazzi, E., (1995) Int. J. Oncol., 6, p. 659Iuliano, L., (1992) Lipids, 27, p. 349Lowry, O.H., (1951) Biol Chem., 193, p. 265Omura, T., Sato, R., (1964) J. Biol. Chem., 239, p. 2371Degterev, I.A., (1990) Pharmac. Chem. J., 24, p. 9Verovskiy, V.N., (1990) Pharmac. Chem. J., 24, p. 20Degterev, I.A., (1993) Bioactive Compounds. Biotransformation and Biological Action, , NOVA Science Publ., New Yor