Background: Kinematic analysis is a method for quantitative assessment applied in different fields of study. In the field of motor development, this analysis may promote better understanding of the acquisition and development of motor skills. Objective: To develop and compare two experimental set-ups for kinematic analysis of head movements relating to eye-head coordination (EHC) in infants. Methods: Two experimental set-ups (A and B) were tested. They differed from each other regarding the numbers and locations of the cameras, and regarding the volume of the calibration system. Results: The accuracy of the two experimental set-ups was 2.47mm, thus indicating that both can provide realistic reconstructions of the movement. The three cameras used in set-up B made it possible to view the full range of motion with at least one of the cameras. This led to improvement of the qualitative analysis and reduction of the time taken to process quantitative data, which was 33% shorter than seen with set-up A. In addition, set-up B presented a better cost-benefit relationship. Conclusions: Although both set-ups were adequate for kinematic analysis of head movements relating to EHC in infants, set-up B is more advantageous. The methodology for set-up B can be used in studies investigating head movements in either typical or atypical infants. 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