Glutathione And Related Enzymes: Biological Roles And Importance In Pathological Processes [glutationa E Enzimas Relacionadas: Papel Biológico E Importância Em Processos Patológicos]

Abstract

Glutathione (GSH) and related enzymes are pivotal for the normal functioning of several important biological processes. In this review we discuss the biosynthesis and the catalytic cycles of glutathione as well as the major GSH-related enzymes. We also present how glutathione and enzymes are involved in cancer and the chromatographic and non-chromatographic methods used to analyze glutathione and/or its derivatives.31511701179Joseph, P.D., Mannervik, B., Ortiz de Montellano, P., (1997) Molecular Toxicology, pp. 152-186. , 1st ed, Oxford University Press: New YorkChambres, I., Harrison, P.R., (1987) Trends Biochem Sci, 12, p. 255Hatfield, D., Diamond, A., (1993) Trends Genet, 9, p. 69Cohen, G., Hochstein, P., (1963) Biochemistry, 2, p. 1420Carsol, M.A., Pouliquen, I., Lesgards, G., Marchi, G., Puigserver, A., Santimoni, M., (1997) Eur. J. Biochem, 247, p. 248Lehmann, C., Wollenberger, U., Brigelius-Flohé, R., Scheller, F.W., (1998) J. Electroanal. 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