EFEK INFUSA BIJI KEMRUNGGI (Caesalpinia crista L.) TERHADAP KADAR GLUKOSA DARAH DAN SGPT, SERTA STRUKTUR HISTOLOGIS HATI DAN GINJAL TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERGLIKEMIK

Abstract

The objective of this research was to know the effect of Kemrunggi (Caesalpinia crista L.) seeds infusion on blood glucose, SGPT level, histological of liver and kidney of hyperglycaemic rats (Rattus norvegicus Berkenhout, 1769). Kemrunggi (C. crista L.) seeds were collected from West Papua and rats (R. norvegicus Berkenhout, 1769) male, Wistar. Rats were divided into 7 groups of 5, 4 groups as control (independent, burden, solvent, and drug) and 3 groups used as a treatment groups that were given 10%, 20% and 30% Kemrunggi seeds infusion. The hyperglycaemic rat were made by administering D-glucose monohydrate 6,75 g/kg body weight. The seeds was infundation and was treats to hyperglycaemic rats during seven days. The result showed that on the seventh days, blood glucose level was lowest on independent group (AUC0-300 32421,32). There was no significantly different among infusion treatments, eventhough the 20% infusion group showed the highest percentage of lowering blood glucose value (55,282%). No significantly different among treatments also showed on the lowering SGPT level, at 10%, 20%, and 30%, were 26,13%, 10,02%, and 17,55% respectively. Kemrunggi (C. crista L.) seeds infusion were caused degeneration on liver histological (cloudy sweeling, hydrophic), steatosis, and karyolisis, but showed no significantly different with control group. It also were caused degeneration on kidney histological (cloudy sweeling, hydrophic), plasmolysis, and karyolysis. It could be concluded that infusion of Kemrunggi seeds at 20% lowering blood glucose effectively and also lowering SGPT level at 10-30% concentration. Kemrunggi seeds infusion did not have any effect on liver histological structure, but not on kidney