EVALUASI ADVERSE DRUG REACTIONS DAN EFEKTIVITAS PENGGUNAAN KETOROLAK PADA PASIEN PASCA BEDAH SARAF DI RUMAH SAKIT UMUM PENDIDIKAN DR. WAHIDIN SUDIROHUSODO MAKASSAR

Abstract

Pain is often experienced by patients treated in the hospital and is themost frequently reported events in post-surgical patients. Pain management in post-surgery patients are necessary to improve the quality of life for patients hospitalized patient include long associated with patient care costs and suffering caused by the pain. Ketorolac is widely used as an analgesic for acute postoperative pain restricted to a maximum of 5 days only. Restriction on duration of ketorolac use associated with the incidence of adverse drug reactions include, the incidence of acute renal failure and bleeding disorders. The purpose of the study was to observe and report on the profile of adverse reactions include the effects on renal function and hemostasis as well as the effectiveness of the analgesic ketorolac. Research using pre and post design with prospective study conducted from January 2012 to May 2013 in the post-neurosurgical patients department at dr. Wahidin Sudirohusodo Hospital, Makassar. A total of 20 patients who received ketorolac in comparison to the value of the glomerular filtration rate (GFR), bleeding time (BT), Blood Clotting Time (CT), prothrombin time (PT) and International Normalized Ratio (INR) between before and after patients received ketorolac. The value of the Visual Analog Scale (VAS) score was compared from day 1 until day 5 on ketorolac consumption. One of 20 patients (5%) who use ketorolac for 5 days had decrease GFR by 66.7%. Whereas for hemostasis testing showed that ketorolac can influence the hemostatic seen from increasing on BT (0,0