KEJADIAN KARDIOVASKULAR MAYOR PADA PENDERITA INFARK MIOKARD AKUT DENGAN ELEVASI SEGMEN ST (IMA-EST) YANG DILAKUKAN TERAPI TROMBOLITIK DIBANDING INTERVENSI KORONER PERKUTAN (IKP) PRIMER SELAMA PERAWATAN DI RUMAH SAKIT

Abstract

Background: A study comparing thrombolytic therapy and primary percutaneous coronary intervention (PCI) in patients with STEMI has been reported in developed countries. There has not been many studies reporting the outcome of pirmary PCI in developing countries where this intervention had just recently performed. Objective: To observed the major cardiovascular events in patients with STEMI who recieved thrombolytic therapy compared with primary PCI during hospitalization. Methodology and Methods: we performed retrospective cohort study using medical record of STEMI patients with the onset <12 hours who recieved thrombolytic therapy and primary PCI at Dr. Sardjito Hospital at Yogyakarta starting January 1 st , 2008 until March 31 st , 2010. Clinical outcomes: primary clinical outcomes: major cardiovascular events are composit of cardiovascular death, reinfarction and stroke during hospitalization. Secondary clinical outcomes: post-infarction angina pectoris, heart failure, cardiogenic shock and side effects of bleeding. Results: from 78 patients who recieved thrombolytic therapy and 53 patients with primary PCI we found that major cardiovascular events during hospitalization was not significantly different,10.3% vs 9.4% (RR 1.0