Madangones A and B, two new neolignans from Beilschmiedia madang Blume and their bioactivities

Abstract

Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 M. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 µM, respectively