目的 再现强直性脊柱炎（ankylosing spondylitis, AS）的家族特征，为本病的临床诊断、预防提供佐证。方法 收集一组具家族特征性强直性脊柱炎病例，追踪发病历史、治疗过程。结果 血清阴性脊柱关节病（seronegative spondyloarthropath, SpA）──强直性脊柱炎发病隐匿，尤其在幼年期发病症状不典型，易于误诊。其中出现足底骨刺、胸痛、手指腊肠样红肿发炎、肢体不适等症状，有强直性脊柱炎家族史者，提示极有可能为本病。结论 强直性脊柱炎由于发病隐匿，导致幼年期及发病早期易被忽略而误诊，ESSG（欧洲脊柱关节病研究组）关于血清阴性脊柱关节病诊断和分类标准以及Amor的诊断和分类标准对于本病的早期诊断具有重要的临床价值。Objective: To show the traits of ankylosing spondylitis (AS) in family and to provide the evidences for the clinic diagnosis and prevention. Methods: To collect a group of familial AS cases to trace the cases history and cureing processes. Results: AS is one kind of the Seronegative Spodyloarthropathy (SpA) , whose symptoms is not conspicuous and typical, especioully in the childhood, not easy to be diagnosed. If one had the symptoms as plantar,chest pain, finger swolen and limbs discomfort etc., it should be considered the family history as reference for diagnosis. Conclusion: AS may be ignored or misdiagnosed in the childhood due to its occult onset. ESSG on the diagnosis of seronegative spondyloarthropathy and classification criteria, and Amor criteria for diagnosis and classification have important clinical value in the early diagnosis of this disease
