Astroviruses (AstVs) are viral agents in the Family Astroviridae that are able to infect and cause disease in a wide variety of host species. Despite the broad host range and ability to cause disease, there are significant gaps in knowledge concerning the epidemiology, ecology, and pathophysiology of a majority of AstVs. Porcine astroviruses (PoAstVs) are distributed worldwide. Five PoAstV lineages (PoAstV1–PoAstV5) have been identified perhaps reflecting diverse origins, interspecies transmission, and recombination events, some presumably with human strains. In the past decade, different members of the genus Mamastrovirus have been associated with neurologic disease in humans, bovine, mink and most recently, porcine astrovirus 3 (PoAstV3) in swine
