Objective:To evaluate the state of the application of antibiotics in the outpatient prescription for seeking the facts of the irrational of application of antibiotics and take the relevant intervention measures. Methods: Cases of prescriptions from Jan to Dec,2013 were investigated. The rates of use antibiotics were recorded, and the irrational application of outpatient prescription antibiotics was analyzed. Results: The utilization rate of the outpatient prescription antibiotics was 43%, and the irrational usage rate was 5%, which mainly showed in using antibiotics without symptom; irrational usage and dose, irrational combined application of drugs and etc.Conclusion: Appropriate measures should be taken in the irrational use of drugs to ensure the safety of drug application for patients.目的 依据医院门诊处方抗菌药物的使用情况，查找不合理使用的因素，采取相应的干预措施，提高抗菌药物的合理使用率。方法 抽查本院2013年1—12月的门诊处方，统计出抗菌药物的使用率及使用情况，对不合理使用抗菌药物的处方进行分析。结果 门诊处方抗菌药物使用率为43%，涉及96个品种，其中口服药39个；注射剂57个，抗菌药物的不合理使用率达到5%。主要表现：无指征使用抗菌药物；用法、用量不合理；联合用药不合理。结论 针对抗菌药物不合理使用状况，采用相应的干预措施，加强抗菌药物的合理应用，保证患者用药安全，降低医疗费用，减少医疗资源的浪费
