Objective: To explore the clinical efficacy and side effects of buspirone treatment combined with music intervention on generalized anxiety disorder (GAD). Method: 80 enrolled GAD patients were randomly divided into intervention group (buspirone treatment combined with music intervention) and the control group (buspirone treatment only), each group had 40 patients. HAMA (Hamilton Rating Scale for Anxiety) and TESS (Treatment Emergent Symptom Scale) were assessed in the baseline and 1 week, 3 weeks and 6 weeks after each treatment to evaluate the efficacy and side effects. Results: The combined patients were scored significantly less in total HAMA score, the somatic anxiety factor and the psychic anxiety factor after 6-week treatment compared with the control patients (separately 9.63±3.78 vs 12.65±3.76，0.52±0.39 vs 0.69±2.89，0.85±0.28 vs 1.12±0.34, t＝－3.59、－2.20、－3.81, P＜0.01, P＜0.05, P＜0.01). Conclusion: Music intervention could reduce anxious symptoms largely, the clinical efficacy buspirone treatment combined with music intervention is better than the single use of buspirone when GAD patients are treated.目的 探讨音乐干预联合丁螺环酮治疗广泛性焦虑障碍的疗效和副反应。方法 将80例广泛性焦虑障碍患者随机分为音乐干预联合丁螺环酮组（干预组）40例和单用丁螺环酮组（对照组）40例，治疗6周，采用汉密尔顿焦虑量表（Hamilton Rating Scale for Anxiety, HAMA）评定疗效，采用TESS量表（Treatment Emergent Symptom Scale）评定副反应，治疗前、治疗后1周、3周、6周分别评定一次。结果 治疗6周末干预组在HAMA总分、躯体焦虑因子、精神焦虑因子评分上（分别为9.63±3.78，0.52±0.39，0.85±0.28）显著低于对照组（分别为12.65±3.76、0.69±2.89、1.12±0.34），差异具有统计学意义（t＝－3.59、－2.20、－3.81，除躯体焦虑因子P＜0.05，余P均＜0.01）。结论 音乐干预联合丁螺环酮治疗能显著改善焦虑症状，治疗广泛性焦虑障碍的效果优于单用丁螺环酮
