Some strong natural fluctuations of climate in the Eastern Mediterranean (EM) region are shown to be connected to the major tropical systems, e.g., El Nino Southern Oscillation, South Asian Monsoon and hurricanes. Modelling of the severe floods suggests a relation to tropical hurricanes. For a, specific event, high-resolution modelling of the severe flood on December 3-5, 2001. in Israel suggests a relation to hurricane Olga. In order to understand the factors governing the Eastern Mediterranean climate variability in the summer season, the relationship between extreme summer temperatures and the South Asian Monsoon was examined. Other tropical factors, like the Red Sea Trough system and the Saharan dust, also contribute to the Mediterranean climate variability