The project MISS (Minimal invasive smart suture) provides solutions and concepts for several key issues within cardiac surgery. These issues include pre-operative imagebased stenosis detection and planning, intra-operative semiautomatic registration and dynamically adapting of video and angiography data, as well as the presentation of two novel concepts for bypass connection. The proposed solutions are conceptually parts of a closed-loop surgical interaction process and will in the mid-term be connected accordingly