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Spatial patterns of the tau pathology in progressive supranuclear palsy
Authors
A Brodal
A Schrag
+44 more
C Gomez-Haro
DR Williams
DW Dickson
H Braak
I Litvan
I Litvan
I Litvan
I Tellez-Nagel
IRA Mackenzie
JA Steiner
JC Steele
JJ Hauw
K Aoki
K Arima
K Ikeda
M Goedert
M Hattori
M Lacoste De
M Minamu
Nigel J. Cairns
NJ Cairns
NJ Cordata
P Mattila
PL Lantos
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
RA Armstrong
Richard A. Armstrong
RW Hiorns
S Papapetropoulos
SE Daniel
T Komori
T Yamada
U Nath
V Montpetit
Y Fujino
Publication date
1 January 2013
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
Progressive supranuclear palsy (PSP) is characterized neuropathologically by neuronal loss, gliosis, and the presence of tau-immunoreactive neuronal and glial cell inclusions affecting subcortical and some cortical regions. The objectives of this study were to determine (1) the spatial patterns of the tau-immunoreactive pathology, viz., neurofibrillary tangles (NFT), oligodendroglial inclusions (GI), tufted astrocytes (TA), and Alzheimer's disease-type neuritic plaques (NP) in PSP and (2) to investigate the spatial correlations between the histological features. Post-mortem material of cortical and subcortical regions of eight PSP cases was studied. Spatial pattern analysis was applied to the NFT, GI, TA, NP, abnormally enlarged neurons (EN), surviving neurons, and glial cells. NFT, GI, and TA were distributed either at random or in regularly distributed clusters. The EN and NP were mainly randomly distributed. Clustering of NFT and EN was more frequent in the cortex and subcortical regions, respectively. Variations in NFT density were not spatially correlated with the densities of either GI or TA, but were positively correlated with the densities of EN and surviving neurons in some regions. (1) NFT were the most widespread tau-immunoreactive pathology in PSP being distributed randomly in subcortical regions and in regular clusters in cortical regions, (2) GI and TA were more localized and exhibited a regular pattern of clustering in subcortical regions, and (3) neuronal and glial cell pathologies were not spatially correlated. © 2012 Springer-Verlag
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Last time updated on 06/03/2017
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info:doi/10.1007%2Fs10072-012-...
Last time updated on 11/12/2019