Barbieri, Claudia Ruga

Pöppl, Alan Gomes

Journal of Veterinary Internal Medicine

English

Lume 5.8

for age and trilostane use, subclinical group was associated withreduced risk of clinical outcomes (adjusted hazard ratio, 0.28; 95%confidence interval, 0.10–0.77).The results of this study suggest that hypercortisolism in dogsincludes subclinical PDH with an older age, lower post-ACTH stimula-tion cortisol, and lower risk of clinical outcomes compared toovert PDH.EN25Risk-Factors for Feline Hyperthyroidism in Southern Brazil: A Case-Control StudyAlan Gomes Pöppl – Universidade Federal do Rio Grande do Sul; ClaudiaBarbieri – Universidade Federal do Rio Grande do SulHyperthyroidism is an elderly cats’ frequent disease. Its prevalencehas been increasing worldwide. Many evidences raised regardinghyperthyroidism risk-factors. By this way, those factors would haveimplications in the huge geographic prevalence variation observed.The objective of this study was to look for potential environmentalvariables associated with feline hyperthyroidism around Porto Alegrecity, Southern Brazil. A 30-questions questionnaire was applied to28 hyperthyroid feline owners as well as to 55 euthyroid (above8 years of age) feline owners (n:m). Results of univariate analysis wereexpressed as odds ratio (OR) and respective 95% confidence interval(95%IC). Mean age of hyperthyroid cats was 13.2  2.7 years (range:7-18), while euthyroid cats mean age was 11.6  2.4 years (range:8-16) (P < 0.01). Age greater than 12 years was considered as a risk-factor (OR 3.14; 95%CI = 1.10 – 8.97), as well as canned foods expo-sure (OR 2.87; 95%CI = 1.10 - 7.50) as previously described. Bathingfrequency showed an association between higher bathing frequency(weekly/monthly) and hyperthyroidism (OR 7.57; 95%CI = 1.41 -40.55). Other items surveyed, such as the use of plastic accessories,contact with domestic dust, use of endoparasiticides, ectoparasiti-cides, and vaccines, it was not possible to identify any association ofthese variables as risk or protective factors. Previous data suggest thatbathing could have a protective effect cleaning off dust particles fromthe fur. The bath hypothesis as risk-factor needs further studies dueto possible presence of endocrine disruptors linked with thyroid dis-function in cosmetic products.EN26Selegiline and Trilostane Association for Canine Pituitary-DependentHyperadrenocorticism: A Randomized Clinical TrialAlan Gomes Pöpplc – Universidade Federal do Rio Grande do Sul;Guilherme Carvalho de Carvalho – Universidade Federal do Rio Grandedo Sul; Luana Meirelles – Universidade Federal do Rio Grande do Sul;Carolina Da Silva – Universidade Federal do Rio Grande do Sul; WaldemirNeto – Universidade Federal do Rio Grande do Sul; Priscila Furtado –PROVET; Letícia Machado – Universidade Federal do Rio Grande do Sul;Francisco Martins – Universidade Estadual do Ceará; Stella Valle –Universidade Federal do Rio Grande do Sul; Fabioloa Mello –Universidade Federal do Rio Grande do SulCanine pituitary-dependent hyperadrenocorticism (PDH) is a commonendocrine disorder. Clinical management usually demands lifelong tri-lostane therapy, which may cause endogenous ACTH (eACTH)elevation, adrenomegaly, and recurrent dosage adjustments. Selegilinetherapy has been previously indicated for canine PDH treatment at thepituitary level, but not encouraged. However, there have been no stud-ies associating trilostane and selegiline for PDH treatment in dogs. Theaim of this work was to evaluate the clinicopathological features, imag-ing findings, and hormone test results in dogs with PDH treated withtrilostane (Tri) or with trilostane and selegiline (Tri+Sel). Fifteen client-owned dogs diagnosed with spontaneous PDH were evaluated: eightwere treated with Tri and seven with Tri+Sel in a randomized clinicaltrial. Dogs underwent clinical examination, serum biochemical analysis,urinalysis, abdominal ultrasound, and eACTH and post-ACTH cortisolmeasurements on treatment days zero (D0), 30 (D30), 90 (D90), and180 (D180). Patients included in the Tri group were initially treatedwith trilostane at an initial dose of 0.5 mg/kg PO twice daily, whereasthe Tri+Sel group initially received 0.5 mg/kg PO of trilostane twicedaily and 1 mg/kg PO of selegiline once daily. There was no significantdifference at the 95% confidence level in eACTH variation between theTri group (median D0 = 20.85 pg/dL; median D180 = 79.0 pg/dL;p = 0.07) and the Tri+Sel group (median D0 = 103 pg/dL; medianD180 = 98.25; p = 0.57). Both groups showed significant lower post-ACTH cortisol levels at the end of the study (Tri median D0 = 15 μg/dL;D180 = 5.2 μg/dL; p = 0.002 vs. Tri+Sel median D0 = 17.23 μg/dL;D180 = 2.26 μg/dL; p = 0.006). Also, both groups needed trilostanedosage adjustments (p = 0.01). However, no statistical difference wasobserved between the groups at the end of the study regarding eACTHor post-ACTH cortisol levels. Nonetheless, there was minor variation inleft adrenal gland thickness in the Tri+Sel group (left adrenal medianD0 = 0.65 cm; median D180 = 0.71; p = 0.7) when compared with theTri group (left adrenal median D0 = 0.77 cm; median D180 = 0.97 cm;p = 0.09). The same was observed for right adrenal gland thickness (Tri+Sel median D0 = 0.65 cm; median D180 = 0.58 cm; p = 0.2 vs. Trimedian D0 = 0.58 cm; median D180 = 0.77 cm; p = 0.04). Moreover,patients in the Tri+Sel group seemed to have achieved better metaboliccontrol throughout fructosamine and total cholesterol evaluation. Not-withstanding, no differences in clinical control or cognitive function sta-tus were perceived between the groups. The association of selegilinewith trilostane seems to be a safe and promising complementary ther-apy for canine PDH. However, further studies with a larger sample sizeand longer follow-up are needed to clarify the actual effect of thisassociation.EN27Urinary Tract Infection in Canine HyperadrenocorticismAlan Gomes Pöpplc – Universidade Federal do Rio Grande do Sul; LeticiaMachado – Universidade Federal do Rio Grande do Sul; Franciele Maboni– Universidade Federal do Rio Grande do Sul; Stella Valle – UniversidadeFederal do Rio Grande do Sul; Félix González – Universidade Federal doRio Grande do Sul; Camila Riboldi – Universidade Federal do Rio Grandedo Sul; Gustavo Ekman – Universidade Federal do Rio Grande do Sul;Milena Cleff de Oliveira – Universidade Federal do Rio Grande do Sul;Luana Rodrigues – Universidade Federal do Rio Grande do SulOccult urinary tract infection (UTI) is assumed as a common comorbid-ity in canine patients with hyperadrenocorticism (HAC), affecting up to50% of cases at initial diagnosis. However, increased concern about2458 ABSTRACTS

Risk‐factors for feline hyperthyroidism in Southern Brazil : a case‐control study

https://lume.ufrgs.br/bitstream/10183/203849/1/001107040.pdf

Risk‐factors for feline hyperthyroidism in Southern Brazil : a case‐control study

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