Dutra, Vinicius Rodrigues da Rosa

English

Soares, Marcelo Viana

Becker, Elizamari Rodrigues

Lume 5.8

Mothers who exercise during pregnancy can prevent their children from having neurological problems — UFRGS | Universidade Federal do Rio Grande do Sulfile:///C|/Acervo%20Rádio/Maycke/001096662.htm[27/8/2019 09:29:14]A- A A+Studies show that benefits of physical exercise are transgenerational -Photo: Arrondissement de Villeray Saint Michel Parc Extension CC BY-ND 2.0Study analyzes the effects of gestational swimming of rats on baby health and the potential for prevention of activityagainst hypoxia-ischemiaPortuguês | EnglishYou are here: Home › UFRGS › News and Information › Mothers who exercise during pregnancy can prevent their children from having neurological problemsMothers who exercise during pregnancy can prevent their children from havingneurological problemsReporting: Vinícius Rodrigues DutraNeonatal hypoxia-ischemia, which is an event that causes damage to thecentral nervous system, occurs when there is a reduction in the supply ofoxygen to the brain. It is one of the major causes of neurological damagein preterm newborns, leading in 50% of these cases to chronic deficienciesand permanent brain damage, such as cerebral palsy, attention deficithyperactivity disorder (ADHD). Among babies born at term, that is, they arenot preterm, the incidence of hypoxia-ischemia is 1.5 per thousand births, anumber that increases among preterm babies.In his postdoctoral studies, conducted at the Postgraduate Program inBiochemistry at the Universidade Federal do Rio Grande do Sul (UFRGS),neuroscientist Eduardo Sanches, aided by PhD student Luz Elena Carabali,analyzes whether the swimming during pregnancy alters the offspring’sbrain development and decreases the damage caused by hypoxia-ischemialesions. The study was conducted in the Neuroprotection andNeurometabolic Diseases and Brain Ischemia Laboratories, coordinated byProfessors Angela Wyse and Carlos Alexandre Netto, respectively, and theirresults are described in the article Pregnancy swimming causes short andlong-term neuroprotection against hypoxia-ischemia in very immature rats, highlight of its edition in Pediatric Research, magazine of thegroup Nature. In fact, the research shows that the offspring of mothers who used to swim during pregnancy had a lower cognitive deficit,presenting a reduction in the size of the hypoxic-ischemic lesion and a decrease in the negative characteristics that the lesion induces.In the study, 12 female Wistar rats were used, which were divided into two groups: swimmer and sedentary. The first group was submitted to20 minutes of daily swimming during the 21 days of the gestational period, while the second group remained in a box, without exercises, forthe same period. After the birth, a brain lesion was made with the offspring of both groups to obstruct an artery, so limiting the oxygensupply of the brain and generating a hypoxic atmosphere in its encephalon during a certain time. Animals without lesions were maintained inboth groups to the control group. Henceforth, several tests were conducted to compare the possible effects of swimming on the protection ofthe offspring’s brains.Some of the animals underwent behavioral tests. Throughout the lactational phase, memory and reflexes were tested, such as in thestraightening test, in which the rats were placed belly up and time was set for them to turn around, or in the Morris water maze, where theyshould be guided by what they remembered about the environment to find a platform in a water tank. The offspring of mothers which swamhad a performance considerably better in tests compared to the offspring of sedentary mothers.Another group of the rats underwent a biochemical analysis. They were euthanized between 24 and 48 hours after the injury then they hadtheir brains examined, especially the hippocampal region and the cerebral cortex. The activities of Na+/K+-ATPase (sodium and potassiumionic pump) were investigated, for hypoxia-ischemia causes a decrease in the energy supply of the brain and in the function of this pump,which is important for the maintenance of the brain. In addition, the levels of BDNF (Brain Derived Neurotrophic Factor) were also evaluated,because BDNF – a mechanism responsible for cell survival – is believed to be encouraged by physical exercise, being. In both analyzes, theanimals whose mothers had undergone physical exercises had a lower reduction of Na+/K+-ATPase activity and higher levels of BDNFcompared to the animals in the sedentary group, a result which demonstrates that the central nervous system of these animals respondsUFRGS ACADEMIC PROGRAMS STUDENT MOBILITY RESEARCH AND INNOVATION COMMUNITY OUTREACHINTERNATIONAL COOPERATIONMothers who exercise during pregnancy can prevent their children from having neurological problems — UFRGS | Universidade Federal do Rio Grande do Sulfile:///C|/Acervo%20Rádio/Maycke/001096662.htm[27/8/2019 09:29:14]better in the case of damage.Eduardo Sanches recalls that BDNF is an important factor in the prevention of several diseases and that physical exercise is recommended toprevent neurodegenerative diseases, such as Alzheimer and metabolic disorders (such as stroke and hypoxia-ischemia itself). The group choseswimming because it presents better results than treadmill exercise, for example, in which the animal only exercises if it wants, whereas inswimming it has no choice. However, the researcher points out those clinical studies demonstrate that the benefits of any physical exerciseare generally transgenerational – if the parents exercise, their children will gain as a result. "It's a simple and inexpensive strategy comparedto a treatment if the child has any problem during parturition," he says.Translated by Marcelo Viana Soares, under the supervision and translation revision of Professor Elizamari R. Becker (PhD/UFRGS).Universidade Federal do Rio Grande do SulAv. Paulo Gama, 110 - Bairro Farroupilha - Porto Alegre - Rio Grande do Sul CEP: 90040-060 - Fone: +55 51 33086000Directions

Mothers who exercise during pregnancy can prevent their children from having neurological problems

https://lume.ufrgs.br/bitstream/10183/198661/1/001096662.pdf

Mothers who exercise during pregnancy can prevent their children from having neurological problems

Abstract

Similar works

Full text

Available Versions

Lume 5.8