Almeida, Jussara Carnevale de

Beretta, Mileni Vanti

Marques, Camila Lemos

Prates, Raquel Eccel

Rodrigues, Ticiana da Costa

Schaan, Ciglea do Nascimento

Diabetology & Metabolic Syndrome

English

Lume 5.8

MEETING ABSTRACT Open AccessAdiponectin levels and waist circumference,waist-hip ratio and conicity index in type 1diabetes patientsCamila Lemos Marques*, Mileni Vanti Beretta, Raquel Eccel Prates, Filipe Valvassori Nascimento, Ciglea Nascimento,Jussara Carnevale de Almeida, Ticiana da Costa RodriguesFrom 20th Brazilian Diabetes Society CongressPorto Alegre, Brazil. 11-18 November 2015BackgroundAnthropometric measurements are used to evaluate thebody adiposity distribution. Adiponectin is a proteinsynthesized by adipose tissue which has an inverse rela-tionship with obesity and insulin resistance. Previousstudies demonstrated that low plasma adiponectin levelsare associated with type 2 diabetes mellitus and risk ofcardiovascular disease. This study aims to evaluate theassociation between adiponectin levels and anthropo-metric measurements in patients with type 1 diabetesmellitus (T1D).Materials and methodsCross-sectional study in outpatient adults with T1D in ahospital in southern Brazil, data collected from 2008 to2013. The anthropometric measurements used werewaist circumference (WC), waist-hip ratio (WHR),waist-to-height ratio (WHtR), body mass index (BMI),and conicity index (CI) and lipid accumulation product(LAP). Serum adiponectin was measured using a com-mercial ELISA kit (Invitrogen®, USA) and was analyzedin tertiles (tertile 1 ≤ 10.26 µg/mL, tertile 2 between10.27 and 18.27 µg/mL and tertile 3 ≥ 18.28 µg/mL).ResultsThe 122 subjects studied (50.8% women) had mean ageof 38.7±11.3 yrs. and median of adiponectin 13.1 µg/mL(8.8–22.9 µg/mL). Adiponectin was negatively correlatedwith WC (r=-0.19, p=0.04), WHR (r=-0.232, p=0.01)and CI (r=-0.18, p=0.04). Individuals of the first tertileof adiponectin (lowest levels) had higher values of WC,WHR and CI when compared with individuals of theothers tertiles. After gamma regression analyses, adjustedfor age, WC (Beta=-0.03; p<0.001), WHR (Beta=-4.86;p<0.001) and CI (Beta=-5.67; p<0.001) remained negativelyassociated with adiponectin. Variables like BMI, WHtR,LAP, total cholesterol, HDL-cholesterol, LDL-cholesterol,triglycerides, ultra sensitive C-reactive protein and insulinresistance were not associated with adiponectin levels incorrelation analysis.ConclusionsWaist circumference, waist-hip ratio and conicity indexwere associated with low serum adiponectin levels inadults with T1D. The conicity index had a stronger asso-ciation with adiponectin. As anthropometric measure-ments can be easily accessed through physicalexamination and might be indicative of cardiovascularrisk in this population, this information should not beneglected by the health care professionals.Published: 11 November 2015doi:10.1186/1758-5996-7-S1-A86Cite this article as: Marques et al.: Adiponectin levels and waistcircumference, waist-hip ratio and conicity index in type 1 diabetespatients. Diabetology & Metabolic Syndrome 2015 7(Suppl 1):A86.* Correspondence: camilamarques08@gmail.comUFRGS, Porto Alegre, BrazilMarques et al. Diabetology & Metabolic Syndrome 2015, 7(Suppl 1):A86http://www.dmsjournal.com/content/7/S1/A86METABOLIC SYNDROMEDIABETOLOGY & © 2015 Marques et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided theoriginal work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Adiponectin levels and waist circumference, waist-hip ratio and conicity index in type 1 diabetes patients

https://lume.ufrgs.br/bitstream/10183/194214/1/000980359.pdf

Adiponectin levels and waist circumference, waist-hip ratio and conicity index in type 1 diabetes patients

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