Ascoli, Aline Maria

Azambuja, Aline Zimmermann de

Corte, Bruno Pellini

Dalcin, Paulo de Tarso Roth

Faulhaber, Gustavo Adolpho Moreira

Furlanetto, Tania Weber

Marcondes, Natália Aydos

Raimundo, Fabiana Viegas

Scopel, Luciano

Vanacor, Roberta

Lume 5.8

32ª SEMANA CIENTÍFICA DO HOSPITAL DE CLÍNICAS DE PORTO ALEGRE Rev HCPA 2012; 32 (Supl.)                                                                                         131      PREVALENCE OF LOW BONE MINERAL DENSITY AND ASSOCIATED FACTORS IN ADOLESCENTS AND ADULTS PATIENTS WITH CYSTIC FIBROSIS Roberta Vanacor, Fabiana Viegas Raimundo, Natália Aydos Marcondes, Bruno Pellini Corte, Aline Maria Ascoli, Aline Zimmermann de Azambuja, Luciano Scopel, Paulo de Tarso Roth Dalcin, Gustavo Adolpho Moreira Faulhaber, Tania Weber Furlanetto  Background: Survival of cystic fibrosis (CF) patients has increased, so bone health could be important for the quality of life of affected patients. Several studies described lower bone mass density (BMD) in patients with CF, which increased fracture risk. Objective: The aim of this study was to evaluate the prevalence of low BMD as well as to evaluate the factors associated with bone mass in these patients. Methods: BMD was measured by DXA in lumpar spine (L1-L4), in patients ≤19years-old, or lumbar spine and femur (total and neck) in patients ≥20years-old. Evaluations of nutritional status, biochemical parameters, lung function were performed. Medications were obtained from medical records Results: Fifty-eight patients were included in the study (25 males/33females), mean age 23.9 years (16-53). The prevalence of bone mass below the expected range for age at any site was 20.7%. None of the subjects had history of fracture. Lumbar spine Z-score in FC patients correlated positively with BMI (r=0.3, p=0.001), and with the rate of the predicted FEV1 (r=0.415, p=0.022). Mean lumbar spine Z-score were higher in women (p=0.001), in patients with no pancreatic insufficiency (p=0.032), and in patients with  no  hospitalization  in  the  last  3  months  (p=0.02).  BMI  (p=  0.001),  and  sex  (p=0.001)  were independently associated with the Z-score in the lumbar spine. Conclusion: Low bone mass is a frequent problem in patients with CF, being associated BMI, which could reflect disease intensity, and male sex. A larger effort should be made to keep these patients wellnourished.        

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Prevalence of low bone mineral density and associated factors in adolescents and adults patients with cystic fibrosis

Prevalence of low bone mineral density and associated factors in adolescents and adults patients with cystic fibrosis

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