Nursing patients with cancer is associated with intensity of emotional engagement, that can result in compassion fatigue and burnout, with nurses leaving the profession as a result. This literature review seeks to answer the question ‘do mindfulness interventions reduce burnout in oncology nurses?’ A systematic database search resulted in 294 papers, that were filtered using inclusion/exclusion criteria. Thirty-one papers were read in full and critically appraised. Seven original studies provided the final data. Findings are presented under the headings of overall effectiveness of the diverse selection of interventions, physical and psychological impact on nurses (including skills acquisitions to improve resilience) and the practicalities of using emotional support interventions. Mindfulness interventions can reduce levels of compassion fatigue and burnout in oncology nurses. Techniques learned can be used in practice to help reduce stress and support coping in challenging situations. Support can reduce the emotional cost of caring, reduce staff absence due to ill health and reduce the number of people leaving the profession/department