Ablin, J.N.

Ben Simon, E.

Cavazza, M.

Charles, Fred

Goldwway, N.

Greental, A.

Hendler, T.

Lubin, O.

Sharon, H.

Weizman, L.

Bournemouth University Research Online

pdfcrowd.comDate: Monday, November 6, 2017Session Title: Fibromyalgia, Soft TissueDisorders, Regional and Specific ClinicalPain SyndromesSession Type: ACR Concurrent AbstractSessionSession Time: 4:30PM-6:00PMABSTRACT NUMBER: 1872The Effect of EEG-Amygdala-Related-Neurofeedback on REMLatency in Patients with FibromyalgiaNoam Goldwway , Haggai Sharon , Eti Ben Simon , Libat Weizman , Ayam Greental , Omer Lubin ,Marc Cavazza , Fred Charles , Talma Hendler  and Jacob N. Ablin , Functional Brain Center, WohlInstitute for Advanced Imaging, Tel-Aviv Sourasky Medical Centre, Tel Aviv, Israel, School ofComputing, Teesside University, United Kingdom, Middlesbrough, United Kingdom, Departmentof Creative Technology, Bournemouth University, Bournemouth, United Kingdom, Rheumatology,Rheumatology Institute, Tel Aviv, Tel Aviv, IsraelMeeting: 2017 ACR/ARHP Annual MeetingDate of first publication: September 18, 2017Keywords: fibromyalgia, neuroimaging and sleepSESSION INFORMATIONBackground/Purpose:Fibromyalgia syndrome (FMS) is a condition characterized by widespread pain, sleep disturbanceand chronic fatigue, and mood disorder .FMS was suggested to represent a prototype of centralnervous system hypersensitivity (central sensitivity-CS). While the mechanisms underlying CSremain incompletely understood, a role for limbic and sleep related dysregulation has beenargued. The aim of the current study was to examine the feasibility of fMRI-inspired ElectricalFinger Print (EFP) of the amygdala as a probe for NeuroFeedback (amyg-EFP NF) training for FMpatients. We expected to find improved sleep quality among trainees successful indownregulating amygdala activity.Methods:Thirty four FMS patients (3M:31F, average age 35.6 SD=11.82) underwent 10 sessions of amyEFP-NF, targeting down-regulation of the amygdala. Nine patients received rewarding sham NF andserved as a control group. The 24 patients that received real feedback were divided intosuccessful (succ+) (N=13) and unsuccessful (succ-) (N=12) feedback learners. Two interfaces wereused to give the feedback: Auditory feedback and multi-modal virtual reality feedback. Anobjective outcome measure of sleep quality was taken using the WatchPAT device before andafter NF trainingResults: Repeated measures ANOVA for feedback learning provided significant results (F=3.23p=0.05), indicating that succ+ subjects displayed improved ability to regulate their amyEFP signalfollowing treatment, in comparison to succ- and sham participants. The three groups also differedin REM latency improvement: repeated measures ANOVA for REM latency was significant (F=3.5571 1 1 1 1 12 3 1 4 1234pdfcrowd.comin REM latency improvement: repeated measures ANOVA for REM latency was significant (F=3.557p=0.04), indicating that only succ+ subjects displayed longer REM latency following amyEFP-NF.Furthermore, the change in REM latency was correlated with feedback learning only in the succ+group (R=0.497 p=0.05)Conclusion:In order to improve the sleep quality of patients suffering from central sensitivity disorder wetargeted the amygdala, a limbic hub that is known to be affected by sleep impairment. We showfeedback-specific effect of improved REM latency, a well-known marker for mood disorder. Thisstudy provides novel evidence of neurofeedback specific effect on objective sleep measures inFMS patients.Disclosure: N. Goldwway, None; H. Sharon, None; E. Ben Simon, None; L. Weizman, None; A.Greental, None; O. Lubin, None; M. Cavazza, None; F. Charles, None; T. Hendler, None; J. N. Ablin,None.To cite this abstract in AMA style:Goldwway N, Sharon H, Ben Simon E, Weizman L, Greental A, Lubin O, Cavazza M, Charles F,Hendler T, Ablin JN. The Effect of EEG-Amygdala-Related-Neurofeedback on REM Latency inPatients with Fibromyalgia [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10).http://acrabstracts.org/abstract/the-effect-of-eeg-amygdala-related-neurofeedback-on-rem-latency-in-patients-with-fibromyalgia/. Accessed October 5, 2017.ACR Meeting Abstracts - http://acrabstracts.org/abstract/the-effect-of-eeg-amygdala-related-neurofeedback-on-rem-latency-in-patients-with-fibromyalgia/

The Effect of EEG-Amygdala-Related-Neurofeedback on REM Latency in Patients with Fibromyalgia [abstract]

The Effect of EEG-Amygdala-Related-Neurofeedback on REM Latency in Patients with Fibromyalgia [abstract]

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