The aim of this study was to determine whether combining potential biomarkers of fruit and vegetables is better at predicting FV intake within FV intervention studies than single biomarkers

A Alberg

A Drewnowski

A Gibson

AC Kurilich

Alanna J. McGrath

C Sanchez-Moreno

CE Neville

Charlotte E. Neville

Chris R. Cardwell

Claire R. Draffin

D Hunter

DO McCall

DR Campbell

EW Steyerberg

FJ He

FR Baldrick

G Block

H Boeing

H Crews

Ian S. Young

IR Wallace

J Vioque

Jane McEneny

Jayne V. Woodside

JJM Castenmiller

JP Vuilleumier

JV Woodside

Katherine M. Appleton

KL Tucker

KS Krogholm

L Hussein

L Marchand Le

Lesley L. Hamill

LI Mennen

LS Freedman

M Dehghan

Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, Spencer JP, Kennedy OB, Tuohy KM, Minihane AM, et al.: FLAVURS Study Group

MBE Livingstone

MC Jansen

MF Chong

MI Heinonen

Michelle C. McKinley

MJ Brown

NE Craft

NZ Unlu

P Ferrari

P Riso

PF Jacques

R Newson

RD Lee

S Zino

SA Bingham

SE Nielsen

SJ Padayatty

W Kalt

WK Al-Delaimy

YT Szeto

McGrath, A. J.

Hamill, L. L.

Cardwell, C. R.

Draffin, C. R.

Neville, C. E.

Appleton, Katherine

McEneny, J.

McKinley, M. C.

Young, I. S.

Woodside, J. V.

Bournemouth University Research Online

Combining vitamin C and carotenoid biomarkers better predicts fruit and vegetable intake than individual biomarkers in dietary intervention studies.

PURPOSE: The aim of this study was to determine whether combining potential biomarkers of fruit and vegetables is better at predicting FV intake within FV intervention studies than single biomarkers.DESIGN: Data from a tightly controlled randomised FV intervention study (BIOFAV; all food provided and two meals/day on weekdays consumed under supervision) were used. A total of 30 participants were randomised to either 2, 5 or 8 portions FV/day for 4 weeks, and blood samples were collected at baseline and 4 weeks for plasma vitamin C and serum carotenoid analysis. The combined biomarker approach was also tested in three further FV intervention studies conducted by the same research team, with less strict dietary control (FV provided and no supervised meals).RESULTS: The combined model containing all carotenoids and vitamin C was a better fit than either the vitamin C only (P &lt; 0.001) model or the lutein only (P = 0.006) model in the BIOFAV study. The C-statistic was slightly lower in the lutein only model (0.85) and in the model based upon factor analysis (0.88), and much lower in the vitamin C model (0.68) compared with the full model (0.95). Results for the other studies were similar, although the differences between the models were less marked.CONCLUSIONS: Although there was some variation between studies, which may relate to the level of dietary control or participant characteristics, a combined biomarker approach to assess overall FV consumption may more accurately predict FV intake within intervention studies than the use of a single biomarker. The generalisability of these findings to other populations and study designs remains to be tested. </p

McGrath, Alanna J.

Hamill, Lesley L.

Cardwell, Chris R.

Draffin, Claire R.

Neville, Charlotte E.

Appleton, Katherine M.

McEneny, Jane

McKinley, Michelle C.

Young, Ian S.

Woodside, Jayne V.

Queen's University Belfast Research Portal

Combining vitamin C and carotenoid biomarkers better predicts fruit and vegetable intake than individual biomarkers in dietary intervention studies

Crossref

European Journal of Nutrition

Combining vitamin C and carotenoid biomarkers better predicts fruit and vegetable intake than individual biomarkers in dietary intervention studies.

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Bournemouth University Research Online

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Queen's University Belfast Research Portal