Health literacy represents the degree to which patients can understand and act upon health information and is highly relevant to surgical care. This cross-sectional study sought to determine the prevalence and the independent predictors of limited health literacy in patients with Dupuytren’s disease. The Newest Vital Sign, a validated and reliable tool, was selected to measure health literacy. An exploratory multivariable logistic regression model was used to identify the predictors of limited health literacy. Almost half (44%) of eligible patients (n=185) had limited health literacy. Having a lower household income or being an immigrant led to an increased in the odds of having limited health literacy by nearly 5 and 4-fold respectively. Considering the high prevalence of limited health literacy and the challenge in identifying predictors in the clinical setting, universal measures of support, such as tools aimed to facilitate communication with all patients, would be of high value.M.Sc