BackgroundSensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies.MethodsIn this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD.ResultsIn typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits.ConclusionsThese findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD

Begum-Ali, Jannath

Garg, Shruti

Green, Jonathan

Johnson, Mark H

Jones, Emily JH

Kolesnik-Taylor, Anna

Mason, Luke

Quiroz, Isabel

STAARS and EDEN Teams

English

PubMed

Background: sensory modulation difficulties are common in children with conditions such as Autism  Spectrum  Disorder  (ASD),  and  could  contribute  to  other social  and  non-social symptoms. Positing a causal role for sensory processing differences requires observing atypicalsensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective  studies. Methods:  in this  longitudinalstudy,  we examined  auditory repetition suppression and   change   detection at 5   and   10-months   ininfants   with and   without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: in typically developing infants, suppression to vowel repetition and enhancedresponses  to vowel/pitchchangedecreased with  ageoverposterior  regions,  becoming  more frontally-specific;  age-related  change  was  diminished  in  the NF1group. Whilst  both groups detected  changes  in  vowel  and  pitch,  the NF1group  were  largely  slower to  show  a differentiated neural  response. Auditory responses  did  not  relate  to  later  language but  were related  to  later  ASD  traits. Conclusions:  these  findings  represent  the  first  demonstration  of atypical brain  responses  to  soundsin  infants  with NF1, and  suggests  they  may  relate  to  the likelihood of later ASD

Begum Ali, Jannath

Kolesnik-Taylor, A.

Quiroz, I.

Garg, S.

Green, J.

Johnson, Mark H.

Jones, Emily J.H.

Birkbeck Institutional Research Online

Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofribramatosis Type I

BACKGROUND: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. METHODS: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. RESULTS: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. CONCLUSIONS: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD

Apollo (Cambridge)