A Novel Mechanism for Gabapentin Actions: Up-regulation of δGABAA Receptors

Abstract

Gabapentin is a widely used anticonvulsant and analgesic drug that also causes anxiolysis, sedation and ataxia. The mechanisms underlying these effects are poorly understood. Previously, we showed that gabapentin increases a tonic inhibitory conductance in hippocampal neurons that is generated by 5 subunit- and subunit-containing GABAM.Sc.2018-03-01 00:00:0