NRC Research Press (a division of Canadian Science Publishing)
Doi
Abstract
This study investigated the impact of raising plasma beta-hydroxybutyrate (β-OHB) through ingestion of ketone salts on substrate oxidation and performance during cycling exercise. Ten healthy adult males (23 ± 3 years, BMI 25 ± 3 kg/m2, VO2peak 45 ± 10 ml/kg/min) were recruited to complete two experimental trials. Before enrollment in the experimental conditions, baseline anthropometrics and cardiorespiratory fitness (VO2peak) were assessed and familiarization to the study protocol was provided. On experimental days, participants reported to the laboratory in the fasted state and consumed either 0.3 g/kg β-OHB ketone salts or a flavor-matched placebo 30 minutes prior to engaging in cycling exercise. Subjects completed steady-state exercise at 30%, 60%, and 90% ventilatory threshold (VT) followed by a 150 kJ cycling time trial. Respiratory exchange ratio (RER) and total substrate oxidation were derived from indirect calorimetry. Plasma glucose, lactate, and ketones were measured at baseline, 30 minutes post-supplement, post-steady-state exercise, and immediately following the time trial. Plasma β-OHB was elevated from baseline and throughout the entire protocol in the ketone condition (pThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
