Due to the complexities of tissue repair or regeneration processes, effective clinical strategies have been impaired by both poor delivery of therapeutic agents to the site of injury and a lack of sustained release that is required for long-term efficacy. In this thesis, a strategy for delivering protein therapeutics in a localized and sustained fashion is presented within the context of these regenerative medicine challenges. An affinity-based system was developed whereby transient interactions between complementary binding partners were used to slow the diffusional release of a therapeutic from a polymeric delivery matrix. The Src homology 3 (SH3) domain, which binds a library of SH3-binding peptides, with varying affinity (10Ph.D
