The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment

Alahuhta, M.

Bomble, Y. J.

Bufton, J.C.

Bullock, A.N.

Caba, C.

Cao, H.

Davies, O.R.

Desfosses, A.

Dunne, M.

Fidelis, K.

Goulding, C.W.

Gurusaran, M.

Gutsche, I.

Harding, C.J.

Hartmann, M.D.

Hayes, C.S.

Joachimiak, A.

Kryshtafovych, A.

Leiman, P.G.

Lepore, R.

Loppnau, P.

Lovering, A.L.

Lunin, V.V.

Michalska, K.

Mir‐Sanchis, I.

Mitra, A.

Moult, J.

Phillips Jr, G.N.

Pinkas, D.M.

Rice, P.A.

Schwede, T.

Tong, Y.

Topf, Maya

Veraszto, H.A.

Walton, J.D.

Proteins Structure Function and Bioinformatics

Lepore, Rosalba

Kryshtafovych, Andriy

Alahuhta, Markus

Veraszto, Harshul A.

Bomble, Yannick J.

Bufton, Joshua C.

Bullock, Alex N.

Caba, Cody

Cao, Hongnan

Davies, Owen R.

Desfosses, Ambroise

Dunne, Matthew

Fidelis, Krzysztof

Goulding, Celia W.

Gurusaran, Manickam

Gutsche, Irina

Harding, Christopher J.

Hartmann, Marcus D.

Hayes, Christopher S.

Joachimiak, Andrzej

Leiman, Petr G.

Loppnau, Peter

Lovering, Andrew L.

Lunin, Vladimir V.

Michalska, Karolina

Mir‐Sanchis, Ignacio

Mitra A.K.

Moult, John

Phillips Jr, George N.

Pinkas, Daniel M.

Rice, Phoebe A.

Tong, Yufeng

Walton, Jonathan D.

Repository for Publications and Research Data

Target highlights in CASP13: Experimental target structures through the eyes of their authors

Mir‐sanchis, Ignacio

Mitra, Alok

Schwede, Torsten

University of Birmingham Research Portal

English

Target highlights in CASP13:experimental target structures through the eyes of their authors

Lepore, S.

Kryshtafovyc, A.

Alahuthu, M.

Verasztó, H.

Bomble, Y.

Bufton, J.

Bullock, A.

Davies, O.

Goulding, C.

Harding, C.

Hartmann, M.

Hayes, C.

Leiman, P.

Lovering , A.

Lunin, V.

Mir-Sanchis, I.

Mould, J.

Phillips , G.

Pinkas, D.

Rice, P.

Topf, M.

Walton, J.

MPG.PuRe

International audienceThe functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment

Veraszto, Harshul

Bomble, Yannick

Bufton, Joshua

Bullock, Alex

Davies, Owen

Goulding, Celia

Harding, Christopher

Hartmann, Marcus

Hayes, Christopher

Leiman, Petr

Lovering, Andrew

Lunin, Vladimir, Y.

Mir-Sanchis, Ignacio

Mitra, Ak

Phillips, George

Pinkas, Daniel

Rice, Phoebe

Walton, Jonathan

Hal - Université Grenoble Alpes

Bufton, Josh C

Bullock, Alex N

Coa, Hongnan

Gurusanran, Manickam

Lunin, Vladimir Y

Philips, George

Tong, Yefeng

Explore Bristol Research

                          Lepore, R., Kryshtafovych, A., Alahuhta, M., Veraszto, H., Bomble, Y.,Bufton, J. C., Bullock, A. N., Caba, C., Coa, H., Davies, O.,Desfosses, A., Dunne, M., Fidelis, K., Goulding, C., Gurusanran, M.,Gutsche, I., Harding, C., Hartmann, M., Hayes, C. S., ... Schwede, T.(2019). Target highlights in CASP13: experimental target structuresthrough the eyes of their authors. Proteins: Structure, Function, andBioinformatics. https://doi.org/10.1002/prot.25805Peer reviewed versionLink to published version (if available):10.1002/prot.25805Link to publication record in Explore Bristol ResearchPDF-documentUniversity of Bristol - Explore Bristol ResearchGeneral rightsThis document is made available in accordance with publisher policies. Please cite only thepublished version using the reference above. Full terms of use are available:http://www.bristol.ac.uk/red/research-policy/pure/user-guides/ebr-terms/ Table 1. CASP13 target highlights. Columns indicate Target ID, PDB ID, Experimental Method, Resolution, Stoichiometry, Size and CASP13 assessment results. For each target, the accuracy of the best model 1 is provided both at the level of individual protomers (best GDT-TS and corresponding IDDT score) and full assembly (best QS-score).   Target PDB Method Resolution (Å) Stoichiometry Size CASP13 assessment       Protomer Assembly       GDT-TS IDDT QS-score T0969 6CCI X-ray 1.85 A1 487 58.19 0.51 - T0958 6BTC X-ray 2.18 A1 96 80.84 0.69 - T0954 6CVZ X-ray 1.80 A1 350 72.02 0.66 - T0970 6G57 X-ray 2.80 A2 97 67.94 0.28 0.64 T0961 6SD8 X-ray 1.50 A4 505 91.65 0.80 0.91 T1009 6DRU X-ray 2.70 A2 718 71.24 0.64 0.18 T0999 N/A X-ray 3.00 A2 1589 80.39 0.73 0.82 H0953 6F45 X-ray 1.70 A3B1 72 249 54.48 40.12 0.63 0.40 0.37 H0957 6CP8 X-ray 2.20 A1B1 163 164 45.22 60.97 0.57 0.57 0.07 H0968 6CP9 X-ray 2.55 A2B2 126 116 71.40 78.70 0.61 0.66 0.14 H0980 6GNX X-ray 2.90 A2B2 111 52 54.81 - 0.45 - 0.08 H1021 6RAP EM 3.30 A6B6C6 149 354 295 75.67 68.70 36.77 0.65 0.58 0.57 0.33 H1022 6RBK EM 3.40 A6B3 229 529 43.61 62.25 0.55 0.59 0.43 TABLE S1. CASP13 target providers.  # Contibutor Country Institution # Contibutor Country Institution 1 Tom Peat Australia CSIRO 19 Xiaochen Bai USA UT SouthWest MC 2 Leila Lo Leggio Denmark U Kobenhavn 20 George Minasov USA NorthWestern U 3 Ambroise Desfosses France IBS, Grenoble 21 Lindsey Spiegelman USA  UC San Diego 4 Marianne Ilbert France CNRS, Paris 22 Chi-Lin Tsai USA UTMD Anderson 5 Michael Groll Germany Tech U Munchen 23 Manal Swairjo USA San Diego State 6 Andrei Lupas, Marcus Hartmann Germany Max Planck Tübingen 24 Andrzej Joachimiak,  Karolina Michalska, Kemin Tan USA Argonne Lab 7 Noa Keren Israel Ben Gurion U 25 Thomas Szyperski USA U Washington 8 Kaspars Tars Latvia BRCS, Riga 26 Gaetano Montelione USA U Rutgers 9 Shabir Najmudin Portugal U Lisbon 27 Garry Buchko USA Pacific NW Natl Lab 10 Stefan Arold Saudi Arabia KAUST 28 Petr Leiman USA U Texas MB 11 Mark van Raaij Spain CSIS, Madrid 29 Damian Ekiert USA New York U  12 Tilman Schirmer  Switzerland U Basel 30 George Phillips, Jonathan Clinger, Mitchell Miller USA U Rice 13 Brian Trevor Sewell So. Africa U Cape Town 31 Hong Zhou USA UC Los Angeles 14 Brian Marsden UK /Canada SGC, Oxford/Toronto 32 Hongnan Cao USA Georgia I Tech 15 Owen Davies UK U Newcastle 33 Henrique Pereira USA L Berkeley Lab 16 Arnaud Basle UK U Newcastle 34 Oliver Clarke USA Columbia U 17 Andrew Lovering UK U Birmingham 35 Phoebe Rice USA U Chicago 18 Adam Frost USA UC San Francisco 36 Marcus Alahuhta USA Natl Renewable Energy Lab 

Veraszto, Harshul A

Bomble, Yannick J

Bufton, Joshua C

Davies, Owen R

Goulding, Celia W

Harding, Christopher J

Hartmann, Marcus D

Hayes, Christopher S

Leiman, Petr G

Lovering, Andrew L

Lunin, Vladimir V

Mitra, AK

Phillips, George N

Pinkas, Daniel M

Rice, Phoebe A

Walton, Jonathan D

eScholarship - University of California

HAL-CEA

https://www.research.ed.ac.uk/files/251650345/Proteins_2019_Lepore_Target_highlights_in_CASP13_Experimental_target_structures_through_the_eyes_of_their_authors.pdf

Target highlights in CASP13: experimental target structures through the eyes of their authors

Target highlights in CASP13: experimental target structures through the eyes of their authors

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MPG.PuRe

Hal - Université Grenoble Alpes

University of Birmingham Research Portal

Explore Bristol Research

eScholarship - University of California

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