Chondrokola Rosh (CKR) is a traditional metallic Ayurvedic preparation
widely used by the rural and ethnic people of Bangladesh in dysuria. It
is a preparation of various roasted metals (Hg and Cu), non-metal
(sulphur and Mica) and medicinal herbs. Considering the controversy
over the risk of toxic heavy metals in Ayurvedic herbo-mineral
preparations, toxicological parameters on liver functions were
investigated. A single dose of 100mg/kg body weight of the preparation
was administered orally to the rats of both sexes for ninety days. In
this evaluation a statistically significant (p<0.001) increase of
serum albumin levels in male (17%) and female (15%) rat groups were
observed. On the other hand, the plasma bilirubin level was decreased
50% and 28% respectively in both rats groups. But no remarkable
differences were observed in plasma protein, sGPT, sGOT and ALP
activities from their corresponding control values. This study showed
that CKR had no remarkable toxic effect on liver of the animals despite
the presence of traces of transformed heavy metals
