Background: Recurrent spontaneous abortion (RSA) is one of the most
common health complications with a strong genetic component. Several
genetic disorders were identified as etiological factors of hereditary
X linked RSA. However, more genetic factors remain to be identified.
Objective: In this study we performed linkage analysis on a large X
linked RSA pedigree to find a novel susceptibility locus for RSA.
Materials and Methods: A linkage scan using 11 microsatellites was
performed in 27 members of a large pedigree of hereditary X-linked RSA.
Two point parametric Linkage was performed using Superlink v 1.6
program. Results: Evidence of linkage was observed to markers at Xq23,
DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60,
respectively. Conclusion: Identified locus in this study may carry a
responsible gene in RSA. Narrowing down of this region may leads to
identification of this gene