This study was undertaken to investigate the leaf part of the plant for
analgesic and anti-inflammatory. The ethanol extract of Ficus
iteophylla leaves (100, 200, and 400mgkg-1, i.p) was evaluated for
analgesic and anti-inflammatory activities. The analgesic effect was
studied using acetic acid-induced abdominal constriction and hot plate
test in mice, while the antiinflammatory effect was investigated using
carrageenan induced paw oedema in rats. The ethanol extract at
100mgkg-1, 200mgkg-1, and 400mgkg-1 significantly (P< 0.05)
inhibited acetic acid induced writhes by 1.50 ± 0.43, 3.0 ±
0.82 and 1.0 ± 0.82 respectively. It also exhibited significantly
(P< 0.05) anti-inflammatory by 0.11 ± 0.02, 0.11 ± 0.03,
0.08 ± 0.01 respectively. The preliminary phytochemical screening
of the plant extract revealed the presence of flavonoids, steroids,
tannins and saponins while the effect of flavonoids, steroids and
tannins on analgesic and inflammatory has been reported. The
intraperitoneal median lethal dose (LD50) value of the extract was
found to be 3807.8 mgkg-1 body weights. The result obtained from this
study shows that the extract of Ficus iteophylla contained
phytochemical constituents with analgesic and anti-inflammatory
activities, therefore the leaf part of the plant could be used in the
management of pain and inflammatory conditions
