Medknow Publications on behalf of Indian Pharmacological Society
Abstract
Objectives: The antioxidant potential of gossypin and nevadensin, two
flavonoid compounds, were evaluated by in vitro methods. Materials and
Methods: Gossypin, nevadensin, and the reference standard, butylated
hydroxyl toluene (BHT), were evaluated for DPPH (1,
1-diphenyl-2-picrylhydrazyl), nitric oxide, superoxide, and hydroxyl
radical scavenging activity. Results: Gossypin and BHT showed the
potential for significant DPPH radical inhibition of up to 88.52 and
91.45% at 100 µg/ml concentration. With a 100 µg/ml
concentration of gossypin, the in vitro nitric oxide, superoxide, and
hydroxyl radical scavenging activity was found to be 74.00, 74.22, and
67.15%, respectively; and with 100 µg/ml of BHT the corresponding
values were 82.24, 81.76, and 73.03% of inhibition, respectively.
Conclusion: The study results showed that gossypin has significant
antioxidant activity