Objective: Fibrous hamartoma of infancy (FHI) is a rare, benign soft
tissue tumor that typically occurs within the first two years of life.
It has a specific histologic appearance comprising of three different
mesenchymal tissues with variable proportions in an organoid fashion.
The clinical course is typically benign with excellent prognosis. We
report two cases of this rare lesion and review its cilinicopathologic
characteristics. Case Presentation: The first case was a 15-month-old
girl who had a subcutaneous mass in the right axillary region and the
other one was an 18-month-old boy with a mass on the medial surface of
his right ankle. The masses were successfully excised. After 6 and 30
months follow up no recurrence occurred. Conclusion: Although the
clinical and imaging findings of FHI are quite similar to those of
malignant soft tissue tumor, histologic characteristics of this tumor
will guide to the definite diagnosis that will prevent aggressive and
mutilating procedures
